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My CartCAS：60200-06-8
Molecular Formula：C8H8Cl3N3O4S2
Molecular Weight：380.66
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 60200-06-8 |
| Name | Clorsulon |
| Molecular Formula | C8H8Cl3N3O4S2 |
| Molecular Weight | 380.66 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 262-100-2 |
| MDL | MFCD00072006 |
| SMILES | C1=C(C(=CC(=C1N)S(=O)(=O)N)S(=O)(=O)N)C(=C(Cl)Cl)Cl |
| InChIKey | QOVTVIYTBRHADL-UHFFFAOYSA-N |
| InChI | InChI=1S/C8H8Cl3N3O4S2/c9-7(8(10)11)3-1-4(12)6(20(14，17)18)2-5(3)19(13，15)16/h1-2H，12H2，(H2，13，15，16)(H2，14，17，18) |
| PubChem CID | 43231 |
| Target Point | Parasite |
| Passage | Anti-infection |
| Background | It is a compound with antiparasitic activity. |
| Biological Activity | Clorsulon 是一种口服有效的杀虫剂，是3-磷酸甘油酸和ATP的竞争性抑制剂，Ki值为0.29 mM。[1-2] |
| Data Literature Source | [1]. Mrozik H，et al. 4-amino-6-(trichloroethenyl)-1，3-benzenedisulfonamide，a new，potent fasciolicide. J Med Chem. 1977 Sep;20(9): 1225-7. [2]. Schulman MD，et al. Mechanism of action of MK-401 against Fasciola hepatica: inhibition of phosphoglycerate kinase. Mol Biochem Parasitol. 1982 Mar;5(3): 133-45. [3]. Meaney M，et al. Transmission electron microscope study of the ultrastructural changes induced in the tegument and gut of Fasciola hepatica following in vivo drug treatment with clorsulon. Parasitol Res. 2004 Feb;92(3): 232-41. |
| Unit | Bottle |
| Specification | 250mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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