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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > CisaprideCAS：81098-60-4
Molecular Formula：C23H29ClFN3O4
Molecular Weight：465.95
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 81098-60-4 |
| Name | Cisapride |
| Molecular Formula | C23H29ClFN3O4 |
| Molecular Weight | 465.95 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 279-689-7 |
| MDL | MFCD03305346 |
| SMILES | COC1CN(CCC1NC(=O)C2=CC(=C(C=C2OC)N)Cl)CCCOC3=CC=C(C=C3)F |
| InChIKey | DCSUBABJRXZOMT-IRLDBZIGSA-N |
| InChI | InChI=1S/C23H29ClFN3O4/c1-30-21-13-19(26)18(24)12-17(21)23(29)27-20-8-10-28(14-22(20)31-2)9-3-11-32-16-6-4-15(25)5-7-16/h4-7，12-13，20，22H，3，8-11，14，26H2，1-2H3，(H，27，29)/t20-，22+/m1/s1 |
| PubChem CID | 6917698 |
| Target Point | 5-HT Receptor |
| Passage | Neuronal Signaling；GPCR & G Protein |
| Background | It is a potent 5-HT4 receptor agonist and hERG inhibitor. |
| Biological Activity | Cisapride 是一种口服活性 5-HT4 受体激动剂，其 EC50 值为 140 nM。是一种 hERG 阻断剂，IC50 值为 9.4 nM。是一种胃动力药，可刺激胃肠道运动活动。[1-4] |
| IC50 | hERG channel: 9.4nM(IC50)[1] |
| Data Literature Source | [1]. Manabe N，et al. New-generation 5-HT4 receptor agonists: potential for treatment of gastrointestinal motility disorders. Expert Opin Investig Drugs. 2010 Jun;19(6): 765-75. [2]. Sung KW，et al. Effect of mosapride on Kv4.3 potassium channels expressed in CHO cells. Naunyn Schmiedebergs Arch Pharmacol. 2013 Oct;386(10): 905-16. [3]. Mine Y，et al. Comparison of effect of mosapride citrate and existing 5-HT4 receptor agonists on gastrointestinal motility in vivo and in vitro. J Pharmacol Exp Ther. 1997 Dec;283(3): 1000-8. [4]. Motavallian A，et al. Does Cisapride，as a 5HT(4) Receptor Agonist，Aggravate the Severity of TNBS-Induced Colitis in Rat Gastroenterol Res Pract. 2012;2012: 362536. |
| Unit | Bottle |
| Specification | 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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