{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > EltanexorCAS：1642300-52-4
Molecular Formula：C17H10F6N6O
Molecular Weight：428.29
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 1642300-52-4 |
| Name | Eltanexor |
| Molecular Formula | C17H10F6N6O |
| Molecular Weight | 428.29 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD30489739 |
| SMILES | C1=C(C=C(C=C1C(F)(F)F)C(F)(F)F)C2=NN(C=N2)C=C(C3=CN=CN=C3)C(=O)N |
| InChIKey | JFBAVWVBLRIWHM-AWNIVKPZSA-N |
| InChI | InChI=1S/C17H10F6N6O/c18-16(19，20)11-1-9(2-12(3-11)17(21，22)23)15-27-8-29(28-15)6-13(14(24)30)10-4-25-7-26-5-10/h1-8H，(H2，24，30)/b13-6+ |
| PubChem CID | 86345880 |
| Target Point | CRM1 |
| Passage | Membrane Transporter&Ion Channel |
| Background | It is an oral bioactive inhibitor of XPO1 (exportin 1, CRM1), which inhibits XPO1-dependent nuclear output by directly targeting XPO1, showing strong anti-leukemia activity. |
| Biological Activity | Eltanexor 是具有口服生物活性的XPO1 (CRM1)抑制剂。在AML细胞系，IC50范围为20-211 nM。[1-2] |
| Data Literature Source | [1]. Etchin J，et al. KPT-8602，a second-generation inhibitor of XPO1-mediated nuclear export，is well tolerated and highly active against AML blasts and leukemia-initiating cells. Leukemia. 2017 Jan;31(1): 143-150. [2]. Hing ZA，et al. Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies. Leukemia. 2016 Dec;30(12): 2364-2372. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
