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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > EfonidipineCAS：111011-63-3
Molecular Formula：C34H38N3O7P
Molecular Weight：631.66
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Off-white to light yellow Solid
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| CAS | 111011-63-3 |
| Name | Efonidipine |
| Molecular Formula | C34H38N3O7P |
| Molecular Weight | 631.66 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Off-white to light yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00865899 |
| SMILES | CC1=C(C(C(=C(N1)C)P2(=O)OCC(CO2)(C)C)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OCCN(CC4=CC=CC=C4)C5=CC=CC=C5 |
| InChIKey | NSVFSAJIGAJDMR-UHFFFAOYSA-N |
| InChI | InChI=1S/C34H38N3O7P/c1-24-30(33(38)42-19-18-36(28-15-9-6-10-16-28)21-26-12-7-5-8-13-26)31(27-14-11-17-29(20-27)37(39)40)32(25(2)35-24)45(41)43-22-34(3，4)23-44-45/h5-17，20，31，35H，18-19，21-23H2，1-4H3 |
| PubChem CID | 119171 |
| Target Point | Calcium Channel |
| Passage | Membrane Transporter&Ion Channel |
| Background | Efonidipine is an L - and T-type calcium channel blocker that causes vasodilation and decreased cardiac automaticity. |
| Biological Activity | Efonidipine 是一种L型和T型钙离子通道阻滞剂，可引起血管舒张和心脏自律性降低。能抑制醛固酮从肾上腺分泌。[1-2] |
| Data Literature Source | [1]. Kumfu S，et al. T-type calcium channel blockade improves survival and cardiovascular function in thalassemic mice. Eur J Haematol. 2012 Jun;88(6): 535-48. [2]. Imagawa K，et al. Inhibitory effect of efonidipine on aldosterone synthesis and secretion in human adrenocarcinoma (H295R) cells. J Cardiovasc Pharmacol. 2006 Jan;47(1): 133-8. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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