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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Others > Efaproxiral SodiumCAS：170787-99-2
Molecular Formula：C20H22NNaO4
Molecular Weight：363.38
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 170787-99-2 |
| Name | Efaproxiral Sodium |
| Molecular Formula | C20H22NNaO4 |
| Molecular Weight | 363.38 |
| Solubility | Soluble in Water/DMSO ≥2mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD02093864 |
| SMILES | InChI=1S/C20H23NO4.Na/c1-13-9-14(2)11-16(10-13)21-18(22)12-15-5-7-17(8-6-15)25-20(3，4)19(23)24;/h5-11H，12H2，1-4H3，(H，21，22)(H，23，24);/q;+1/p-1 |
| InChIKey | InChI=1S/C20H23NO4.Na/c1-13-9-14(2)11-16(10-13)21-18(22)12-15-5-7-17(8-6-15)25-20(3，4)19(23)24;/h5-11H，12H2，1-4H3，(H，21，22)(H，23，24);/q;+1/p-1 |
| InChI | InChI=1S/C20H23NO4.Na/c1-13-9-14(2)11-16(10-13)21-18(22)12-15-5-7-17(8-6-15)25-20(3，4)19(23)24;/h5-11H，12H2，1-4H3，(H，21，22)(H，23，24);/q;+1/p-1 |
| PubChem CID | 2725048 |
| Target Point | Others |
| Passage | Others |
| Background | It is an allosteric regulator of hemoglobin (Hb) synthesis, which can reduce the binding affinity of hemoglobin oxygen (O2). |
| Biological Activity | Efaproxiral Sodium是一种人工合成的血红蛋白（Hb）变构修饰剂，可降低血红蛋白与氧气（O2）的结合亲和力，并在体外放疗过程中增强缺氧肿瘤的氧合作用。[1-2] |
| Data Literature Source | [1]. Donnelly ET，Liu Y，Rockwell S. Efaproxiral (RSR13) plus oxygen breathing increases the therapeutic ratio of carboplatin in EMT6 mouse mammary tumors. Exp Biol Med (Maywood). 2006 Mar;231(3): 317-21. [2]. Hou H，et al. The effects of Efaproxyn (efaproxiral) on subcutaneous RIF-1 tumor oxygenation and enhancement of radiotherapy-mediated inhibition of tumor growth in mice. Radiat Res. 2007 Aug;168(2): 218-25. |
| Unit | Bottle |
| Specification | 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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