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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > DronedaroneCAS：141626-36-0
Molecular Formula：C31H44N2O5S
Molecular Weight：556.76
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 141626-36-0 |
| Name | Dronedarone |
| Molecular Formula | C31H44N2O5S |
| Molecular Weight | 556.76 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00910331 |
| SMILES | CCCCC1=C(C2=C(O1)C=CC(=C2)NS(=O)(=O)C)C(=O)C3=CC=C(C=C3)OCCCN(CCCC)CCCC |
| InChIKey | ZQTNQVWKHCQYLQ-UHFFFAOYSA-N |
| InChI | InChI=1S/C31H44N2O5S/c1-5-8-12-29-30(27-23-25(32-39(4，35)36)15-18-28(27)38-29)31(34)24-13-16-26(17-14-24)37-22-11-21-33(19-9-6-2)20-10-7-3/h13-18，23，32H，5-12，19-22H2，1-4H3 |
| PubChem CID | 208898 |
| Target Point | Sodium Channel; Calcium Channel; Adrenergic Receptor |
| Passage | Membrane Transporter&Ion Channel;Endocrinology & Hormones;GPCR & G Protein;Neuronal Signaling |
| Background | It is an effective blocker of a variety of ion currents, including potassium currents, sodium currents, and L-shaped calcium currents, and exhibits an anti-adrenergic effect by noncompetitively binding to the adrenergic receptor. |
| Biological Activity | Dronedarone (SR 33589)是胺碘酮(HY-14187)的衍生物，是III类抗心律失常药物，用于房颤(AF)和心房扑动的研究。Dronedarone是多种离子电流的有效阻滞剂，包括钾电流、钠电流和l型钙电流，并通过与β-肾上腺素能受体的非竞争性结合表现出抗肾上腺素能作用。Dronedarone是CYP3A4的底物和中度抑制剂。[1] |
| Data Literature Source | [1]. Patel C，et al. Circulation. 2009 Aug 18;120(7): 636-44. doi: 10.1161/CIRCULATIONAHA.109.858027. [2]. Sawicka KM，et al. Influence of dronedarone (a class III antiarrhythmic drug) on the anticonvulsant potency of four classical antiepileptic drugs in the tonic-clonic seizure model in mice. J Neural Transm (Vienna). 2019 Feb;126(2): 115-122. |
| Unit | Bottle |
| Specification | 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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