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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > IpatasertibCAS：1001264-89-6
Molecular Formula：C24H32ClN5O2
Molecular Weight：458
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to light yellow Solid
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| CAS | 1001264-89-6 |
| Name | Ipatasertib |
| Molecular Formula | C24H32ClN5O2 |
| Molecular Weight | 458 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to light yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD22124514 |
| SMILES | C[C@@H]1C[C@H](C2=C1C(=NC=N2)N3CCN(CC3)C(=O)[C@H](CNC(C)C)C4=CC=C(C=C4)Cl)O |
| InChIKey | GRZXWCHAXNAUHY-NSISKUIASA-N |
| InChI | InChI=1S/C24H32ClN5O2/c1-15(2)26-13-19(17-4-6-18(25)7-5-17)24(32)30-10-8-29(9-11-30)23-21-16(3)12-20(31)22(21)27-14-28-23/h4-7，14-16，19-20，26，31H，8-13H2，1-3H3/t16-，19-，20-/m1/s1 |
| PubChem CID | 24788740 |
| Target Point | Akt |
| Passage | PI3K/Akt/mTOR |
| Background | It is a selective, ATP-competitive pan-Akt inhibitor. |
| Biological Activity | Ipatasertib (GDC-0068) is a highly selective and ATP-competitive pan-Akt inhibitor with IC50s of 5， 18 and 8 nM for Akt1， Akt2 and Akt3， respectively.[1-2] |
| Data Literature Source | [1]. Blake JF，et al. Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors. J Med Chem. 2012 Sep 27;55(18):8110-27. [2]. Lin J，et al. Targeting activated Akt with GDC-0068，a novel selective Akt inhibitor that is efficacious in multiple tumor models. Clin Cancer Res. 2013 Apr 1;19(7):1760-72. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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