Anti-GSR Polyclonal Antibody
Cat: K112241P
Summary:
| 【Product name】：Anti-GSR Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：2936 | 【Swiss Prot】：P00390 |
| 【Observed】：47/56kDa | |
| 【Tested applications】：IHC,WB | |
| 【Recommended dilution】：WB 1:1000-3000. IHC 1:100-300. | |
| 【Immunogen】：Recombinant protein of human GSR | |
| 【Public Immunogen Range】：1-289aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found.
Verified picture:
Western blot analysis with GSR antibody diluted at 1:2000;Lane: HeLa,L-02,Colon cancer.
Immunohistochemistry of paraffin-embedded Human colorectal cancer with GSR antibody diluted at 1:200.