Anti-Phospho-P38 MAPK(Thr180+Tyr182) Polyclonal Antibody
Cat: K010011P
Summary:
| 【Product name】：Anti-Phospho-P38 MAPK(Thr180+Tyr182) Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：1432 | 【Swiss Prot】：Q16539 |
| 【Tested applications】：IHC,FCM,IF,WB | |
| 【Recommended dilution】：WB 1:500-2000. IHC 1:100-500. FCM 1μg/Test. IF 1:100-500. | |
| 【Immunogen】：A synthetic peptide of human p38 MAPK around the phosphorylation site of Thr180/Tyr182: M(p-T)G(p-Y)VA | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases(MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Verified picture:
Western blot analysis with Phospho-P38 MAPK (Thr180 + Tyr182) antibody diluted at 1:300;Lane: Mouse Muscle Rat Muscle.
Immunohistochemistry of paraffin-embedded rat brain with Phospho-P38 MAPK (Thr180 + Tyr182) antibody diluted at 1:500.