Anti-BABAM2 Polyclonal Antibody
Cat: K111971P
Summary:
| 【Product name】：Anti-BABAM2 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Octanoic acid-ammonium sulfate precipitation |
| 【Gene ID】：9577 | 【Swiss Prot】：Q9NXR7 |
| 【Tested applications】：IHC,WB | |
| 【Recommended dilution】：WB 1:1000-3000.;IHC 1:50-200. | |
| 【Immunogen】：Recombinant protein of human BABAM2 | |
| 【Public Immunogen Range】：1-383aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX (PubMed:17525341, PubMed:19261746, PubMed:19261749, PubMed:19261748).In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer (PubMed:21282113, PubMed:19261748).Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:19214193, PubMed:24075985, PubMed:25283148, PubMed:26195665).Within the BRISC complex, acts as an adapter that bridges the interaction between BABA
Verified picture:
Western blot analysis with BABAM2 antibody diluted at 1:2000;Lane: HT29.
Immunohistochemistry of paraffin-embedded Human colorectal cancer with BABAM2 antibody diluted at 1:100.