Anti-BCAP31 Polyclonal Antibody
Cat: K111474P
Summary:
| 【Product name】：Anti-BCAP31 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：10134 | 【Swiss Prot】：P51572 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:50-200. | |
| 【Immunogen】：A synthetic peptide of human BCAP31 | |
| 【Public Immunogen Range】：55-105/246aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Functions as a chaperone protein (PubMed:9396746, PubMed:18287538). Is one of the most abundant endoplasmic reticulum (ER) proteins (PubMed:9396746, PubMed:18287538). Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD) (PubMed:9396746, PubMed:18287538). Also serves as a cargo receptor for the export of transmembrane proteins (By similarity). Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by stimulating the translocation of NDUFS4 and NDUFB11 from the cytosol to the mitochondria via interaction with TOMM40 (PubMed:31206022). In response to ER stress, delocalizes from the ER-mitochondria contact sites and binds BCL2 (PubMed:31206022). May be involved in CASP8-mediated apoptosis (PubMed:10958671).
Verified picture:
Immunohistochemistry of paraffin-embedded Human colorectal cancer with BCAP31 antibody diluted at 1:100.
Immunohistochemistry of paraffin-embedded Human thyroid cancer with BCAP31 antibody diluted at 1:100.