Anti-PARP1 (Cleaved-Gly215) Polyclonal Antibody
Cat: K111115P
Summary:
| 【Product name】：Anti-PARP1 (Cleaved-Gly215) Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Octanoic acid-ammonium sulfate precipitation |
| 【Gene ID】：142 | 【Swiss Prot】：P09874 |
| 【Tested applications】：WB,IHC,ELISA | |
| 【Recommended dilution】：WB 1:1000-3000. IHC 1:50-200. | |
| 【Immunogen】：A synthetic peptide of human PARP1 | |
| 【Public Immunogen Range】：180-230/1014aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]
Verified picture:
Western blot analysis with PARP1 antibody diluted at 1:2000;Lane: PC12,THP-1.
Immunohistochemistry of paraffin-embedded Human prostate cancer with PARP1 antibody diluted at 1:100.
Immunohistochemistry of paraffin-embedded Human breast cancer with PARP1 antibody diluted at 1:100.