Anti-USP12 Polyclonal Antibody
Cat: K110708P
Summary:
| 【Product name】：Anti-USP12 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：219333 | 【Swiss Prot】：O75317 |
| 【Tested applications】：WB,IHC | |
| 【Recommended dilution】：WB 1:2000-5000. IHC 1:50-200. | |
| 【Immunogen】：A synthetic peptide of human USP12 | |
| 【Public Immunogen Range】：15-65/370aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR20 and WDR48 to have a high activity (PubMed:19075014, PubMed:27373336). Not involved in deubiquitination of monoubiquitinated FANCD2 (PubMed:19075014). In complex with WDR48, acts as a potential tumor suppressor by positively regulating PHLPP1 stability (PubMed:24145035).
Verified picture:
Western blot analysis with USP12 antibody diluted at 1:3000;Lane: A549.
Immunohistochemistry of paraffin-embedded Human colorectal cancer with USP12 antibody diluted at 1:100.
Immunohistochemistry of paraffin-embedded Human renal cancer with USP12 antibody diluted at 1:100.