Anti-KCTD13 Polyclonal Antibody
Cat: K110701P
Summary:
| 【Product name】：Anti-KCTD13 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Octanoic acid-ammonium sulfate precipitation |
| 【Gene ID】：253980 | 【Swiss Prot】：Q8WZ19 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:100-300. | |
| 【Immunogen】：A synthetic peptide of human KCTD13 | |
| 【Public Immunogen Range】：10-60/329aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission (PubMed:19782033). The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome (PubMed:19782033) Degradation of RHOA regulates the actin cytoskeleton and promotes synaptic transmission (By similarity).
Verified picture:
Immunohistochemistry of paraffin-embedded Human prostate cancer with KCTD13 antibody diluted at 1:200.