Anti-ERCC6L Polyclonal Antibody - SAlexa Fluor 568
Cat: K110605P - SAlexa Fluor 568
Summary:
| 【Product name】：Anti-ERCC6L Polyclonal Antibody - SAlexa Fluor 568 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：54821 | 【Swiss Prot】：Q2NKX8 |
| 【Tested applications】：WB,IHC | |
| 【Recommended dilution】：WB 1:1000-3000. IHC 1:100-300. | |
| 【Immunogen】：Recombinant protein of human ERCC6L | |
| 【Public Immunogen Range】：832-1250aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin (PubMed:17218258). Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328).
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