Anti-ARHGAP18 Polyclonal Antibody
Cat: K110162P
Summary:
| 【Product name】：Anti-ARHGAP18 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：93663 | 【Swiss Prot】：Q8N392 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:50-200. | |
| 【Immunogen】：A synthetic peptide of human ARHGAP18 | |
| 【Public Immunogen Range】：520-570/663aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state (PubMed:21865595). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1 (PubMed:25778702). Regulates cell shape, spreading, and migration (PubMed:21865595).
Verified picture:
Immunohistochemistry of paraffin-embedded Human pancreatic cancer with ARHGAP18 antibody diluted at 1:100.