Anti-IGF1R Polyclonal Antibody
Cat: K009651P
Summary:
| 【Product name】：Anti-IGF1R Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：3480 | 【Swiss Prot】：P08069 |
| 【Tested applications】：ELISA,FCM,IF,ICC,IHC,WB | |
| 【Recommended dilution】：WB 1:500-2000. ELISA 1:5000-10000. IHC 1:100-500. FCM 1μg/Test. ICC 1:100. IF 1:100-500. | |
| 【Immunogen】：A synthetic peptide of human IGF1R | |
| 【Public Immunogen Range】：821-920/1367aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.
Verified picture:
Western blot analysis with IGF1R antibody diluted at 1:300;Lane: Mouse Kidney.