Anti-phospho-IKB alpha (Ser32 + Ser36) Polyclonal Antibody - SAlexa Fluor 488
Cat: K009559P - SAlexa Fluor 488
Summary:
| 【Product name】：Anti-phospho-IKB alpha (Ser32 + Ser36) Polyclonal Antibody - SAlexa Fluor 488 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：4792 | 【Swiss Prot】：P25963 |
| 【Tested applications】：FC ICC IF | |
| 【Recommended dilution】：Flow-Cyt 1:50-200. ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：A synthetic peptide of human IKB alpha around the phosphorylation site of Ser32/36 | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
Verified picture: