Anti-SOCS7 Polyclonal Antibody
Cat: K009536P
Summary:
| 【Product name】：Anti-SOCS7 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：30837 | 【Swiss Prot】：O14512 |
| 【Tested applications】：IHC,WB,ELISA,IF,ICC | |
| 【Recommended dilution】：WB 1:500-2000. ELISA 1:5000-10000. IHC 1:100-500. ICC 1:100-500. IF 1:100-500. | |
| 【Immunogen】：A synthetic peptide of human SOCS7 | |
| 【Public Immunogen Range】：171-270/581aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Verified picture:
Western blot analysis with SOCS7 antibody diluted at 1:1000;Lane: Mouse Cerebrum Mouse Cerebellum Mouse Testis Mouse Stomach Mouse Placenta Rat Cerebrum Rat Cerebellum Rat testis HepG2 Hela MCF-7 HL60 Molt-4.
Immunohistochemistry of paraffin-embedded Mouse embryo tissue with SOCS7 antibody diluted at 1:200
Immunohistochemistry of paraffin-embedded Mouse embryo tissue with SOCS7 antibody diluted at 1:500.