Anti-HIF 2 alpha Polyclonal Antibody - SAlexa Fluor 660
Cat: K009522P - SAlexa Fluor 660
Summary:
| 【Product name】：Anti-HIF 2 alpha Polyclonal Antibody - SAlexa Fluor 660 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：13819 | 【Swiss Prot】：P97481 |
| 【Tested applications】：IHC,WB,ELISA,FCM,IF | |
| 【Recommended dilution】：WB 1:500-2000. ELISA 1:5000-10000. IHC 1:100-500. FCM 1μg/Test. IF 1:100-500. | |
| 【Immunogen】：A synthetic peptide of mouse HIF 2 alpha | |
| 【Public Immunogen Range】：1-130/874aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.
Verified picture: