Anti-PPP3CA Polyclonal Antibody
Cat: K107562P
Summary:
| 【Product name】：Anti-PPP3CA Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：5530 | 【Swiss Prot】：Q08209 |
| 【Tested applications】：IHC,IF | |
| 【Recommended dilution】：IHC 1:100-300.IF 1:50-200. | |
| 【Immunogen】：A synthetic peptide of human PPP3CA | |
| 【Public Immunogen Range】：471-521/521aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca2+-mediated signals (PubMed:15671020, PubMed:18838687, PubMed:19154138, PubMed:23468591). Many of the substrates contain a PxIxIT motif and/or a LxVP motif (PubMed:17498738, PubMed:17502104, PubMed:23468591, PubMed:27974827, PubMed:22343722). In response to increased Ca2+ levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (PubMed:15671020). In response to increased Ca2+ levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion (PubMed:18838687). Dephosphorylates heat shock protein HSPB1 (By similarity). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138). In response to increased Ca2+ levels, regulates NFAT-mediated transcription probably by dephosphorylating NFAT and promoting its nuclear translocation (PubMed:26248042). Dephosphorylates and inacti
Verified picture:
Immunohistochemistry of paraffin-embedded Human breast cancer with PPP3CA antibody diluted at 1:200.
Immunohistochemistry of paraffin-embedded Human lung cancer with PPP3CA antibody diluted at 1:200.
Immunofluorescence analysis of A431 cells using COMMD2 antibody diluted at 1:100.