Anti-CENPA Polyclonal Antibody
Cat: K107533P
Summary:
| 【Product name】：Anti-CENPA Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：1058 | 【Swiss Prot】：P49450 |
| 【Tested applications】：WB,IHC,ELISA | |
| 【Recommended dilution】：WB 1:5000-1:8000. IHC 1:50-200. | |
| 【Immunogen】：A synthetic peptide of human CENPA | |
| 【Public Immunogen Range】：90-140/140aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq].
Verified picture:
Western blot analysis with CENPA antibody diluted at 1:6000;Lane: Jurkat,HeLa,K562,A431,HMC1,MCF7,HL60.
Immunohistochemistry of paraffin-embedded Human colorectal cancer with CENPA antibody diluted at 1:100.