Anti-TCF7L2 Polyclonal Antibody
Cat: K107478P
Summary:
| 【Product name】：Anti-TCF7L2 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：6934 | 【Swiss Prot】：Q9NQB0 |
| 【Tested applications】：WB,IHC | |
| 【Recommended dilution】：WB 1:5000-8000. IHC 1:100-300. | |
| 【Immunogen】：A synthetic peptide of human TCF7L2 | |
| 【Public Immunogen Range】：435-485/619aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.
Verified picture:
Western blot analysis with TCF7L2 antibody diluted at 1:6000;Lane: SW480.
Immunohistochemistry of paraffin-embedded Human ovarian cancer with TCF7L2 antibody diluted at 1:200.
Immunohistochemistry of paraffin-embedded Human pancreatic cancer with TCF7L2 antibody diluted at 1:200.