Anti-SDHB Polyclonal Antibody
Cat: K107471P
Summary:
| 【Product name】：Anti-SDHB Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：6390 | 【Swiss Prot】：P21912 |
| 【Tested applications】：WB,IHC | |
| 【Recommended dilution】：WB 1:8000-12000. IHC 1:25-100. | |
| 【Immunogen】：A synthetic peptide of human SDHB | |
| 【Public Immunogen Range】：30-80/280aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.
Verified picture:
Western blot analysis with SDHB antibody diluted at 1:10000;Lane: Mouse brain.
Immunohistochemistry of paraffin-embedded Human liver cancer with SDHB antibody diluted at 1:50.
Immunohistochemistry of paraffin-embedded Human thyroid cancer with SDHB antibody diluted at 1:50.