Anti-FHIT Polyclonal Antibody
Cat: K107167P
Summary:
| 【Product name】：Anti-FHIT Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：2272 | 【Swiss Prot】：P49789 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:100-300. | |
| 【Immunogen】：A synthetic peptide of human FHIT | |
| 【Public Immunogen Range】：85-135/147aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene.
Verified picture:
Immunohistochemistry of paraffin-embedded Human colorectal cancer with FHIT antibody diluted at 1:200.
Immunohistochemistry of paraffin-embedded Human pancreatic cancer with FHIT antibody diluted at 1:200.