Anti-TBP Polyclonal Antibody
Cat: K008562P
Summary:
| 【Product name】：Anti-TBP Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：6908 | 【Swiss Prot】：P20226 |
| 【Tested applications】：WB,IHC | |
| 【Recommended dilution】：WB 1:500-2000. IHC 1:10-100. | |
| 【Immunogen】：Recombinant protein of human TBP | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 32-39, and expansion of the number of repeats increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease.
Verified picture:
Immunohistochemistry of paraffin-embedded Human prostate cancer with TBP antibody diluted at 1:50.
Western blot analysis with TBP antibody diluted at 1:1000;Lane: MDA-ME-231,MCF7,HepG2,K-562,293T,Jurkat.