Anti-RNF8 Polyclonal Antibody
Cat: K005155P
Summary:
| 【Product name】：Anti-RNF8 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：9025 | 【Swiss Prot】：O76064 |
| 【Tested applications】：WB | |
| 【Recommended dilution】：WB 1:100-500. | |
| 【Immunogen】：Recombinant protein of human RNF8 | |
| 【Public Immunogen Range】：230-485aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest. Alternative splicing results in multiple transcript variants.
Verified picture:
Immunohistochemistry of paraffin-embedded Breast cancer(hu) using RNF8 antibody at dilution of 1:100 (x100 lens,x200 lens).
Immunofluorescence analysis of MCF7 cell using RNF8 antibody. Blue: DAPI for nuclear staining.