Anti-SIAH1 Polyclonal Antibody
Cat: K003364P
Summary:
| 【Product name】：Anti-SIAH1 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：6477 | 【Swiss Prot】：Q8IUQ4 |
| 【Tested applications】：IHC,WB,IF | |
| 【Recommended dilution】：WB 1:500-2000. IHC 1:50-200. IF 1:50-200. | |
| 【Immunogen】：Recombinant protein of human SIAH1 | |
| 【Public Immunogen Range】：1-313aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
Verified picture:
Western blot analysis with SIAH1 antibody diluted at 1:1000;Lane: Mouse kidney.
Immunohistochemistry of paraffin-embedded Rat brain with SIAH1 antibody diluted at 1:100.
Immunofluorescence analysis of L929 cells using SIAH1 antibody diluted at 1:100.