Anti-TPMT Polyclonal Antibody
Cat: K001870P
Summary:
| 【Product name】：Anti-TPMT Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：7172 | 【Swiss Prot】：P51580 |
| 【Tested applications】：WB,IF | |
| 【Recommended dilution】：WB 1:500-2000.IF 1:10-100 | |
| 【Immunogen】：Recombinant protein of human TPMT | |
| 【Public Immunogen Range】：1-245aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X.
Verified picture:
Immunohistochemistry of paraffin-embedded liver cancer(hu)/tonsil(hu) using TPMT antibody at dilution of 1:100 (x100 lens��x200 lens).
Immunofluorescence analysis of U2OS cell using TPMT antibody. Blue: DAPI for nuclear staining.
Western blot analysis with TPMT antibody diluted at 1:1000;Lane: K-562.