Anti-SPNS1 Polyclonal Antibody
Cat: K115011P
Summary:
| 【Product name】：Anti-SPNS1 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Octanoic acid-ammonium sulfate precipitation |
| 【Gene ID】：83985 | 【Swiss Prot】：Q9H2V7 |
| 【Observed】：50kDa | |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:50-200. | |
| 【Immunogen】：A synthetic peptide of human SPNS1 | |
| 【Public Immunogen Range】：330-380/528aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Plays a critical role in the phospholipid salvage pathway from lysosomes to the cytosol (PubMed:36161949).Mediates the rate-limiting，proton-dependent，lysosomal efflux of lysophospholipids，which can then be reacylated by acyltransferases in the endoplasmic reticulum to form phospholipids (PubMed:36161949).Selective for zwitterionic headgroups such as lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE)，can also transport lysophosphatidylglycerol (LPG)，but not other anionic lysophospholipids，sphingosine，nor sphingomyelin (PubMed:36161949).Transports lysophospholipids with saturated，monounsaturated，and polyunsaturated fatty acids，such as 1-hexadecanoyl-sn-glycero-3-phosphocholine，1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine and 1-(4Z，7Z，10Z，13Z，16Z，19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine，respectively (PubMed:36161949).Can also transport lysoplasmalogen (LPC with a fatty alcohol) such as 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine (PubMed:36161949).
Verified picture:
Immunohistochemistry of paraffin-embedded Human colorectal cancer with SPNS1 antibody diluted at 1:100.