Anti-BCDIN3D Polyclonal Antibody
Cat: K114479P
Summary:
| 【Product name】：Anti-BCDIN3D Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：144233 | 【Swiss Prot】：Q7Z5W3 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:50-200. | |
| 【Immunogen】：Recombinant protein of human BCDIN3D | |
| 【Public Immunogen Range】：1-293aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
O-methyltransferase that specifically monomethylates 5'-monophosphate of cytoplasmic histidyl tRNA (tRNA(His，acting as a capping enzyme by protecting tRNA(His from cleavage by DICER1. Also able，with less efficiently，to methylate the 5' monophosphate of a subset of pre-miRNAs，acting as a negative regulator of miRNA processing. The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Was also reported to mediate dimethylation of pre-miR-145; however dimethylation cannot be reproduced by another group which observes a monomethylation of pre-miR-145.
Verified picture:
Immunohistochemistry of paraffin-embedded Human ovarian cancer with BCDIN3D antibody diluted at 1:100.
Immunohistochemistry of paraffin-embedded Human pancreatic cancer with BCDIN3D antibody diluted at 1:100.