Anti-EIF2AK3 Polyclonal Antibody
Cat: K114451P
Summary:
| 【Product name】：Anti-EIF2AK3 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：9451 | 【Swiss Prot】：Q9NZJ5 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:50-200. | |
| 【Immunogen】：Recombinant protein of human EIF2AK3 | |
| 【Public Immunogen Range】：766-1116aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2，leading to its inactivation，and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER)，where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.
Verified picture:
Immunohistochemistry of paraffin-embedded Human pancreatic cancer with EIF2AK3 antibody diluted at 1:100.