Anti-DROSHA Polyclonal Antibody
Cat: K114361P
Summary:
| 【Product name】：Anti-DROSHA Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：29102 | 【Swiss Prot】：Q9NRR4 |
| 【Observed】：159kDa | |
| 【Tested applications】：WB | |
| 【Recommended dilution】：WB 1:1000-3000. | |
| 【Immunogen】：A synthetic peptide of human DROSHA | |
| 【Public Immunogen Range】：25-75/1374aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex，which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus，yielding the precursor miRNA (pre-miRNA)，which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene，canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer. [provided by RefSeq，Sep 2016]
Verified picture:
Western blot analysis with DROSHA antibody diluted at 1:2000;Lane: HMC1,MCF7,293T,A549,Jurkat,Raw264.7,HeLa.