Anti-AGBL4 Polyclonal Antibody
Cat: K114679P
Summary:
| 【Product name】：Anti-AGBL4 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：84871 | 【Swiss Prot】：Q5VU57 |
| 【Observed】：63kDa | |
| 【Tested applications】：IHC,WB | |
| 【Recommended dilution】：WB 1:1000-3000.IHC 1:50-200. | |
| 【Immunogen】：A synthetic peptide of human AGBL4 | |
| 【Public Immunogen Range】：453-503/503aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK. Mediates the deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation (By similarity).
Verified picture:
Western blot analysis with AGBL4 antibody diluted at 1:2000;Lane: Stomach cancer ,Kidney cancer.
Immunohistochemistry of paraffin-embedded Human colorectal cancer with AGBL4 antibody diluted at 1:100.