Anti-Collagen Type III (N-terminal) Polyclonal Antibody - HRP
Cat: K010158P - HRP
Summary:
| 【Product name】：Anti-Collagen Type III (N-terminal) Polyclonal Antibody - HRP | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：1281 | 【Swiss Prot】：P02461 |
| 【Observed】：140kDa | |
| 【Tested applications】：IP,IF,ELISA,IHC,WB | |
| 【Recommended dilution】：WB 1:500-2000. ELISA 1:100-1000. IHC 1:20-200. ICC 1:50-200 | |
| 【Immunogen】：Recombinant protein of human Collagen Type III (N-terminal) | |
| 【Public Immunogen Range】：24-152 aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Type III collagen is a fibrillar forming collagen comprising three α1(III) chains and is expressed in early embryos and throughout embryogenesis (PMID: 9050868). In the adult， type III collagen is a major component of the extracellular matrix in a variety of internal organs and skin. It occurs in most soft connective tissues along with type I collagen (PMID: 2445760). COL3A1 gene encodes type III procollagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV， and with aortic and arterial aneurysms (PMID: 10706896; 2243125; 18389341). This antibody raised against 24-152 aa of prepro α1 (III) chain of human type III procollagen detects type III procollagen at 140-180 kDa and also in some lysates reveals a 70-kDa band which has been reported and may represent a cleaved form of type III procollagen (PMID: 17424834; 19648160; 22802960).
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