Anti-PD-L1/CD274 Monoclonal Antibody - Biotin
Cat: K009977M - Biotin
Summary:
| 【Product name】：Anti-PD-L1/CD274 Monoclonal Antibody - Biotin | 【Source】：Mouse |
| 【Isotype】：IgG1 | 【Purification】：Protein G purification |
| 【Gene ID】：29126 | 【Swiss Prot】：Q9NZQ7 |
| 【Observed】：45-50kDa | |
| 【Tested applications】：WB ELISA IHC ICC | |
| 【Recommended dilution】：WB 1:50-200. ELISA 1:100-1000. IHC 1:20-200. ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：Recombinant protein of human PD-L1/CD274 | |
| 【Public Immunogen Range】：25-241aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
PD-L1， also known as CD274 or B7H1， stands for programmed cell death ligand 1. It is a type I transmembrane protein that is thought to repress immune responses by binding to its receptor (PD1)， thus inhibiting T-cell activation， proliferation， and cytokine production. It contains V-like and C-like immunoglobulin domains. PD-L1 expression is regulated by various cytokines， such as TNF-α or LPS (ISSN: 1848-7718). Increased expression of this protein in certain types of cancers， e.g.， renal cell carcinoma or colon cancer， correlates with poor prognosis.
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