Anti-PERK Polyclonal Antibody - SAlexa Fluor 633
Cat: K010149P - SAlexa Fluor 633
Summary:
| 【Product name】：Anti-PERK Polyclonal Antibody - SAlexa Fluor 633 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：9451 | 【Swiss Prot】：Q9NZJ5 |
| 【Observed】：140kDa | |
| 【Tested applications】：IF,WB | |
| 【Recommended dilution】：WB 1:500-1000. IF 1:50-200. | |
| 【Immunogen】：Recombinant protein of human PERK | |
| 【Public Immunogen Range】：867-1116aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2， leading to its inactivation， and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER)， where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.
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