Anti-TCL1A Polyclonal Antibody
Cat: K113417P
Summary:
| 【Product name】：Anti-TCL1A Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：8115 | 【Swiss Prot】：P56279 |
| 【Observed】：16kDa | |
| 【Tested applications】：IHC,WB | |
| 【Recommended dilution】：WB 1:1000-3000. IHC 1:50-200. | |
| 【Immunogen】：Recombinant protein of human TCL1A | |
| 【Public Immunogen Range】：1-115aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia， in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al.， 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells， but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al.， 2000 [PubMed 10983986]).[supplied by OMIM， Jul 2010]
Verified picture:
Western blot analysis with TCL1A antibody diluted at 1:2000;Lane: Ramos,Raji.
Immunohistochemistry of paraffin-embedded Human tonsil cancer with TCL1A antibody diluted at 1:100.