Anti-RNF111 Polyclonal Antibody - SAlexa Fluor 680
Cat: K113401P - SAlexa Fluor 680
Summary:
| 【Product name】：Anti-RNF111 Polyclonal Antibody - SAlexa Fluor 680 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：54778 | 【Swiss Prot】：Q6ZNA4 |
| 【Observed】：105kDa | |
| 【Tested applications】：IHC,WB | |
| 【Recommended dilution】：WB 1:1000-3000. IHC 1:50-200. | |
| 【Immunogen】：Recombinant protein of human RNF111 | |
| 【Public Immunogen Range】：1-137aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators， like SMAD proteins， and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade， this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
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