The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins， contain 2-9 immunoglobulin-like C2-type domains， and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response， NK-cell mediated clearance， lymphocyte recirculation， and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene.