Anti-TM4SF5 Polyclonal Antibody
Cat: K113156P
Summary:
| 【Product name】：Anti-TM4SF5 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：9032 | 【Swiss Prot】：O14894 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:50-200. | |
| 【Immunogen】：A synthetic peptide of human TM4SF5 | |
| 【Public Immunogen Range】：100-150/197aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Acts as a lysosomal membrane arginine sensor (PubMed:30956113).Forms a complex with MTOR and SLC38A9 on lysosomal membranes in an arginine-regulated manner, leading to arginine efflux which enables the activation of mTORC1 which subsequently leads to RPS6KB1 and EIF4EBP1 phosphorylations (PubMed:30956113).Facilitates cell cycle G1/S phase progression and the translocation of the CDK4-CCND1 complex into the nucleus (PubMed:20399237).CDKN1B and RHOA/ROCK signaling activity are involved in TM4SF5-mediated acceleration of G1/S phase progression (PubMed:20399237).
Verified picture:
Immunohistochemistry of paraffin-embedded Human colorectal cancer with TM4SF5 antibody diluted at 1:100.