Anti-TPH1 Polyclonal Antibody
Cat: K010102P
Summary:
| 【Product name】：Anti-TPH1 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：7166 | 【Swiss Prot】：P17752 |
| 【Observed】：51kDa | |
| 【Tested applications】：WB,IHC,IP | |
| 【Recommended dilution】：WB 1:500-1000. IHC 1:50-100. IP 1:20. | |
| 【Immunogen】：A synthetic peptide of human TPH1 | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of serotonin by converting tryptophan to 5-hydroxy-L-tryptophan. Two isoforms of TPH exist: TPH-1 is mainly expressed in the periphery, whereas the expression of TPH-2 is restricted to neuronal cells and the central nervous system. Most of the serotonin found throughout the body is synthesized by TPH-1 in enterochromaffin cells of the gastrointestinal tract. Targeted disruption of the tph1 gene results in low levels of circulating and tissue serotonin.
Verified picture:
Western blot analysis with TPH1 antibody diluted at 1:1000;Lane: THP-1.