Anti-RyR2 Polyclonal Antibody
Cat: K112956P
Summary:
| 【Product name】：Anti-RyR2 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：6262 | 【Swiss Prot】：Q92736 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:50-200. | |
| 【Immunogen】：A synthetic peptide of human RyR2 | |
| 【Public Immunogen Range】：450-500/4967aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca2+ levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.
Verified picture:
Immunohistochemistry of paraffin-embedded Human thyroid cancer with RyR2 antibody diluted at 1:100.