Anti-CD3G Polyclonal Antibody
Cat: K112615P
Summary:
| 【Product name】：Anti-CD3G Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：917 | 【Swiss Prot】：P09693 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:50-200. | |
| 【Immunogen】：Recombinant protein of human CD3G | |
| 【Public Immunogen Range】：26-114aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098).
Verified picture:
Immunohistochemistry of paraffin-embedded Human colorectal cancer with CD3G antibody diluted at 1:100.