Anti-POU2AF1 Polyclonal Antibody
Cat: K112490P
Summary:
| 【Product name】：Anti-POU2AF1 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Octanoic acid-ammonium sulfate precipitation |
| 【Gene ID】：5450 | 【Swiss Prot】：Q16633 |
| 【Observed】：35kDa | |
| 【Tested applications】：WB | |
| 【Recommended dilution】：WB 1:1000-3000. | |
| 【Immunogen】：Recombinant protein of human POU2AF1 | |
| 【Public Immunogen Range】：1-257aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Transcriptional coactivator that specifically associates with either POU2F1/OCT1 or POU2F2/OCT2 (PubMed:7859290).It boosts the POU2F1/OCT1 mediated promoter activity and to a lesser extent, that of POU2F2/OCT2 (PubMed:7779176).It has no intrinsic DNA-binding activity. It recognizes the POU domains of POU2F1/OCT1 and POU2F2/OCT2 (PubMed:7779176).It is essential for the response of B-cells to antigens and required for the formation of germinal centers (PubMed:7623806, PubMed:7859290).Regulates IL6 expression in B cells as POU2F2/OCT2 coactivator (By similarity).
Verified picture:
Western blot analysis with POU2AF1 antibody diluted at 1:2000;Lane: Raji.