Anti-GSDMD Polyclonal Antibody
Cat: K010048P
Summary:
| 【Product name】：Anti-GSDMD Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：79792 | 【Swiss Prot】：P57764 |
| 【Observed】：53kDa | |
| 【Tested applications】：WB,IF,ELISA,IP,IHC,FCM | |
| 【Recommended dilution】：WB 1:2000-10000. IHC 1:50-500. IF 1:50-500. IP 0.5-4.0ug. FCM 10^6cells+0. 4ug. | |
| 【Immunogen】：Recombinant protein of human GSDMD | |
| 【Public Immunogen Range】：135-484aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
GSDMD is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. GSDMD has been suggested to act as a tumor suppressor. Recently, GSDMD is identified as a new component of inflammasomes, and it is an executor of pyroptosis and required for interleukin-1β secretion. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
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