Background：

Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium， the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear， this may lead to a reduction in basilar membrane motion， altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.