Background：

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain， the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome， affecting limb， apocrine gland， tooth， hair， and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however， the full length nature of one variant has not been determined. [provided by RefSeq， Jul 2008]