 |
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|---|---|---|
| 【ProductName】 |
ALPK1 Antibody Blocking Peptide |
|
| 【Cat NO.】 |
K112760P-Ag |
|
| 【Source】 |
Synthetic |
|
| 【Storage】 |
Store at -20℃，2 years.Avoid freeze/thaw cycles. |
|
| 【Appearance】 |
Lyophilized powder |
|
| 【Swiss Prot】 |
Q96QP1 |
|
| 【Gene ID】 |
80216 |
|
| 【Application】 |
Blocking Peptide of K112760P Antibody |
|
| 【Purification】 |
HPLC |
|
| 【Activity】 |
Not tested |
|
| 【Note】 |
Please allow the product to equilibrate to room temperature in a dry environment before opening the packaging. |
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Background：
Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response， a critical step for pathogen elimination and engagement of adaptive immunity (PubMed:28877472， PubMed:28222186， PubMed:30111836).Specifically recognizes and binds ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose)， a potent PAMP present in all Gram-negative and some Gram-positive bacteria (PubMed:30111836).ADP-Heptose-binding stimulates its kinase activity to phosphorylate and activate TIFA， triggering proinflammatory NF-kappa-B signaling (PubMed:30111836).May be involved in monosodium urate monohydrate (MSU)-induced inflammation by mediating phosphorylation of unconventional myosin MYO9A (PubMed:27169898).May also play a role in apical protein transport by mediating phosphorylation of unconventional myosin MYO1A (PubMed:15883161)