Background：

The giant protein titin， together with its associated proteins， interconnects the major structure of sarcomeres， the M bands and Z discs. The C-terminal end of the titin string extends into the M line， where it binds tightly to M-band constituents of apparent molecular masses of 190 kD and 165 kD. The predicted MYOM2 protein contains 1，465 amino acids. Like MYOM1， MYOM2 has a unique N-terminal domain followed by 12 repeat domains with strong homology to either fibronectin type III or immunoglobulin C2 domains. Protein sequence comparisons suggested that the MYOM2 protein and bovine M protein are identical.